Academic Health Center

Center for Drug Design

Abbas Raza, PhD

AHCCDD2-Image-ARaza_180x222px

Academic Title

Research Assistant Professor
Center for Drug Design

Education

Master's
Chemistry, University of Hyderabad, India
Ph.D.
Organic Chemistry, Indian Institute of Chemical Technology, India
Other Education
Postdoctoral Research, Center for Drug Design, University of Minnesota, Minneapolis, MN; Research Associate, Center for Drug Design, University of Minnesota, Minneapolis, MN

Contact Info

Email
razax003@umn.edu

Phone
612-624-2146

Fax
612-625-2633

Office Address

8-125 Weaver-Densford Hall
308 Harvard Street SE
Minneapolis, MN-55455

Mailing Address

Center for Drug Design
Room 5-130 WDH
1332B (Campus Delivery Code)
308 Harvard St SE
Minneapolis, MN 55455

Research Interests

Dermatology:
Design of functional cosmetic ingredients
Biomimetic DNA repair and anti-skin aging approaches
New photoprotection strategies (Solar UV)

Vitamin C:
In addition to being an antioxidant, ascorbic acid (AA) in its oxidized form, dehydroascorbic acid (DHA) has many important biological functions beyond the AA–DHA cycle. Current research include exploring the other facets of this important molecule and use the knowledge to make an effective dug like molecule.

Antiviral:
HIV-1 Protease inhibitors
HCV NS3 Protease inhibitors

Publications

Publications

  • A Bio-Mimetic Approach to DNA Photoprotection Raza, A.; Ericson, M. E.; Nugent, J. S.; Dreis, C. D.; Vince, R.  J. Invest. Dermatol. 2014, 134, 559–562.
     
  • Photoprotection of DNA (in vitro) by acyclothymidine dinucleosides. Raza, A.; Dreis, C. D.; Vince, R. Bioorg Med Chem Lett. 2013, 23(3), 620-3.
     
  • The Butter Flavorant, Diacetyl, Forms a Covalent Adduct with 2-Deoxyguanosine, Uncoils DNA, and Leads to Cell Death. More, S. S.; Raza, A; Vince, R. J. Agric. Food Chem. 2012, 60 (12), 3311-3317.
     
  • Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications. Raza, A. and Vince, R. ChemBioChem 2011, 12, 1015-1017.
     
  • Design and synthesis of sulfoximine based inhibitors for HIV-1 protease. Raza, A.; Sham, Y. Y. and Vince, R. Bioorg. Med. Chem. Lett. 2008, 18, 5406-5410.
     
  • Solid-Phase Synthesis of Isoxazolines. Raza, A.; Reddy, M. V.; Yadav, J. S; Chandrasekhar, S. J. Comb. Chem. 2002, 4(6), 652-655.
     
  • Synthesis of unusual amino acids: N-(tert-butoxycarbonyl)-L-vinyl glycine and N-(tert-butoxycarbonyl)-L-homophenylalanine. Raza, A.; Takhi, M.; Chandrasekhar, S. Tet. Asymm. 2002, 13(4), 423-428.
     
  • A New Cleavage Strategy for Ester Linked Polymer Supports: Generation of a Tertiary Alcohol Library. Padmaja, M. B.; Raza, A.; Chandrasekhar, S. J. Comb. Chem. (2000), 2(3), 246-248.
     
  • Solid phase-solid state synthesis of N-alkyl imides from anhydrides. Padmaja, M.B.; Raza, A.; Chandrasekhar, S. Synlett, 1999, 1597.
     
  • Novel solid-state reduction of organic functional groups on solid support (Merrifield's resin). Raza, A.; Padmaja, M. B.; Chandrasekhar, S. Synlett 1999, (7), 1061-1062.
     
  • One pot synthesis of acetylated homoallyl alcohols. Mohanty, P. K.; Raza, A.; Chandrasekhar, S. Synth. Commun. 1999, 29(2), 257-262.

Patent

  • Vince, R, Raza, A and Dreis C. Agents that Prevent or Repair Skin Damage, PCT Appl. No. PCT/US2013/021259, 2013

 

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  • Last modified on February 10, 2014