Christine Salomon, PhD
Assistant Professor, Center for Drug Design;
Graduate Faculty, Microbial Engineering;
Adjunct Assistant Professor, Biotechnology Institute
Southampton College, Long Island University, Riverhead, NY (1995)
Scripps Institution of Oceanography, University of California - San Diego, CA (2001)
Postdoctoral Research, University of Minnesota, Minneapolis, MN (2001-2006)
The overarching goal of our research program is to discover novel natural products with useful biological activities. Chemical extracts are obtained from cultures of environmental bacterial and fungi that are collected from diverse field locations. Bioassay guided fractionation is used to purify compounds with activity against a panel of human bacterial and fungal pathogens, cancer cell lines and pathogenic biofilms.
Additional screens include an oxidative protection assay and enhancement of limb regeneration in animal models. Novel compounds with potent biological activities are studied to identify the critical pharmacophores which may provide lead structures for new therapeutics or strategies to treat infectious disease, cancer and neurodegenerative disorders.
Active compounds may also provide useful tools to study biosynthetic pathways, signaling cascades, drug resistance, and novel mechanisms of inhibition. Additional areas of interest include biocontrol of agricultural pathogens and the elucidation and modulation of communication networks among bacterial populations using natural products.
Recent Publications (For detailed publication list: Click Here)
Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins. Hassig CA, Zeng F-Y, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walters MA, Divlianska DB, Roth GP, Wright AE, Reed JC Journal of Biomolecular Screening 2014, doi:10.1177/1087057114536227 (Abstract)
Synthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity. Benoit AR, Schiaffo C, Yang J, Salomon CE, Ji Y, Goodell J, Ferguson, DM. Bioorgic and Medicinal Chemistry Letters 2014, 24, 3014–3017. (Abstract)
Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines. Temburnikar KW, Zimmermann S, Kim NT, Ross CR, Gelbmann C, Salomon CE, Wilson GM, Balzarini J, Seley-Radtke KL. Bioorganic and Medicinal Chemistry 2014, 22, 2113-2122. (Abstract)
Subinhibitory antibiotic concentrations alter nutrient utilization and niche overlap among Streptomyces spp. Vaz P, Bakker M, Salomon CE, Kinkel LL. Plos One 2013, 8 (12): e81064. (Abstract)
Solphenazines A-F: Glycosylated phenazines from Streptomyces sp. strain DL-93. Rusman Y, Oppegard LM, Hiasa H, Gelbmann C, Salomon CE. Journal of Natural Products 2013, 76, 91-96. (Abstract)
Pathogen variation and urea influence selection and success of Streptomyces mixtures in biocontrol. Otto-Hanson LK, Grabau Z, Rosen C, Salomon CE, Kinkel LL. Phytopathology 2013, 103, 34-42. (Abstract)
Total synthesis and biological evaluation of the structure of (+)-transvalencin Z. Nelson KM, Salomon CE, Aldrich CA. Journal of Natural Products 2012, 75, 1037-1043. (Abstract)
Natural products as leads for tuberculosis drug development. Salomon CE, Schmidt LE. Current Topics in Medicinal Chemistry 2012, 12, 735-765. (Abstract)
Dual inhibitors of HIV reverse transcriptase and integrase: Structure-activity-relationship studies on integrase inhibition. Wang Z, Tang J, Salomon C, Dreis C,Vince R. Bioorganic and Medicinal Chemistry 2010, 18, 4202-4211. (Abstract)
Plant signaling compounds alter secondary metabolite production among antagonistic streptomyces. Bakker MG, Salomon CE, Kinkel LL. Phytopathology 2009, 99(6): S7-S8. (Abstract)