Steve Patterson - Research Details

Efficient synthesis of benzamide riboside, a potential anticancer agent. Bonnac LF, Gao GY, Chen L, Patterson SE, Jayaram HN, Pankiewicz KW. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1249-53.  Abstract

Novel, orally effective cyanide antidotes. Nagasawa HT, Goon DJ, Crankshaw DL, Vince R, Patterson SE. J Med Chem. 2007;50(26):6462-4.  Abstract

A novel paradigm for assessing efficacies of potential antidotes against neurotoxins in mice. Crankshaw DL, Goon DJ, Briggs JE, DeLong D, Kuskowski M, Patterson SE, Nagasawa HT. Toxicol Lett. 2007;175(1-3):111-7.  Abstract

Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues. Chen L, Gao G, Felczak K, Bonnac L, Patterson SE, Wilson D, Bennett EM, Jayaram HN, Hedstrom L, Pankiewicz KW. J Med Chem. 2007;50(23):5743-51.  Abstract

Phosphonoxins: rational design and discovery of a potent nucleotide anti-Giardia agent. Suk DH, Rejman D, Dykstra CC, Pohl R, Pankiewicz KW, Patterson SE. Bioorg. Med. Chem. Lett. 2007, 17(10): 2811-16.  Abstract

Rational Design and Synthesis of Novel Nucleotide Anti-Giardia agents. Suk DH, Bonnac L., Dykstra CC, Pankiewicz KW, Patterson SE. Bioorg. Med. Chem. Lett. 2007, 17(10): 2811-16.  Abstract

Probing binding requirements of NAD kinase with modified substrate (NAD) analogues. Bonnac L, Chen L, Pathak R, Gao G, Ming Q, Bennett EM, Felczak K, Kullberg M, Patterson SE, Mazzola F, Magnia G, Pankiewicz KW. Bioorg Med Chem Lett 2007 6(15): 1512-15.  Abstract

Fujita-Ban QSAR analysis and CoMFA study of quinoline antagonists of immunostimulatory CpG-oligodeoxynucleotides. Paliakov E, Henary M, Say M, Patterson SE, Parker A, Manzel L, Macfarlane DE, Bojarski AJ, Strekowski L. Bioorg Med Chem Lett 2007, 15: 324-332.  Abstract

Novel Methylenephosphophosphonate Analogues of Mycophenolic Adenine Dinucleotide. Inhibition of Inosine Monophosphate Dehydrogenase. Rejman D, Olesiak M, Chen L, Patterson SE, Wilson D, Jayaram HN, Hedstrom L, Pankiewicz KW. J Med Chem 49, 5018-5022 (2006).  Abstract

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents. Wang, P.; Hollecker, L.; Pankiewicz, K. W.; Patterson, S. E.; Whitaker, T.; McBrayer, T. R.; Tharnish, P. M.; Stuyver, L. J.; Schinazi, R. F.; Otto, M. J.; Watanabe, K. A. Nucleosides Nucleotides Nucleic Acids 24, 957-960 (2005).  Abstract.

Synthesis and in vitro anti-hcv activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides. Shi, J.; Du, J.; Ma, T.; Pankiewicz, K. W.; Patterson, S. E.; Hassan, A. E.; Tharnish, P. M.; McBrayer, T. R.; Lostia, S.; Stuyver, L. J.; Watanabe, K. A.; Chu, C. K.; Schinazi, R. F.; Otto, M. J. Nucleosides Nucleotides Nucleic Acids 24, 875-879 (2005).  Abstract.

Synthesis and anti-viral activity of a series of D- and L-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system. Shi, J.; Du, J.; Ma, T.; Pankiewicz, K. W.; Patterson, S. E.; Tharnish, P. M.; McBrayer, T. R.; Stuyver, L. J.; Otto, M. J.; Chu, C. K.; Schinazi, R. F.; Watanabe, K. A. Bioorg Med Chem, 13, 1641-1652 (2005).  Abstract.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication. Clark, J. L.; Hollecker, L.; Mason, J. C.; Stuyver, L. J.; Tharnish, P. M.; Lostia, S.; McBrayer, T. R.; Schinazi, R. F.; Watanabe, K. A.; Otto, M. J.; Furman, P. A.; Stec, W. J.; Patterson, S. E.; Pankiewicz, K. W. J Med Chem 48, 5504-5508 (2005).  Abstract.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity. Peiyuan Wang, Laurent Hollecker, Krzysztof W. Pankiewicz, Steven E. Patterson, Tony Whitaker, Tamara R. McBrayer, Phillip M. Tharnish, Robert W. Sidwell, Lieven J. Stuyver, Michael J. Otto, Raymond F. Schinazi, and Kyoichi A. Watanabe, J .Med. Chem. 47(24), 6100-3 (2004).  Abstract.

Synthesis of 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides. Jinfa Du, Steven Patterson, Junxing Shi, Byoung-Kwon Chun, Lieven J. Stuyver and Kyoichi A. Watanabe. Bioorg. Med. Chem. Lett. 14(5), 1243-5 (2004).  Abstract.

Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target. Krzysztof W. Pankiewicz, Steven E. Patterson, Paul L. Black, Hiremagalur N. Jarayam, Dipesh Risal, Barry M. Goldstein, Lieven J. Stuyver, and Raymond F. Schinazi. Curr. Med. Chem. 11(7), 887-900 (2004).  Abstract.

The mechanism of action and antileukemic activity of bis(phosphonate) analogue of mycophenolic adenine dinucleotide (C2-MAD); An alternative for tiazofurin. Patterson SE, Black PL, Clark JL, Risal D, Goldstein BM, Jayaram HN, Schinazi, RF, Pankiewicz KW. 0 Developments in Nucleic Acids, Schinazi RF, Liotta D. eds. Elsevier (2004).

The reaction of alcohols and nucleosides with methylenebis(phosphonic acid dichloride): Facile synthesis of methylenebis-(phosphonic acid) monoesters. Patterson SE, Clark JL, Mason JC, Pankiewicz KW. Developments in Nucleic Acids, Schinazi RF, Liotta D. eds. Elsevier (2004).

Triple-helix DNA selective 2-(2-naphthyl)quinoline intercalators. Strekowski L, Parker AN, Hojjat M, Say M, Zegrocka-Stendel O, Patterson SE, Tanious FA, Wilson WD. Acta Pol Pharm. 61 Suppl: 70-72 (2004).  Abstract

Cofactor analogues as inhibitors of IMP dehydrogenase; design and new synthetic approaches. Inosine Monophosphate Dehydrogenase A Major Therapeutic Target Pankiewicz KW, Patterson SE, Jayaram, HN, Goldstein BM. Pankiewicz KW, Goldstein BM Eds., ACS Symposium Series No. 839, 2003, p.247-282.

Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhea virus agents. Lieven J. Stuyver, Stefania Lostia, Steven E. Patterson, Jeremy L. Clark, Kyoichi A. Watanabe, Michael J. Otto, and Krzysztof W. Pankiewicz. Antivir. Chem. Chemother. 13(6), 345-52 (2002).  Abstract.

Cytotoxicity and cellular differentiation activity of methylenebis(phosphonate) analogs of tiazofurin and mycophenolic acid adenine dinucleotide in human cancer cell lines. Joel A. Yalowitz, Krzysztof W. Pankiewicz, Steven E. Patterson, and Hiremagalur N. Jayaram. Cancer Lett. 181(1), 31-8 (2002).  Abstract.

Novel Inhibitors of Inosine Monophosphate Dehydrogenase. J.L. Clark, S.E. Patterson, J.C. Mason, M.J. Otto, R.F. Schinazi, K.A. Watanabe, D. Risal, B.M. Goldstein and K. Pankiewicz. Coll.Czech.Chem. Comm.Symp.Ser. 5, 256 (2002).

Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia. Krzysztof W. Pankiewicz, Krystyna B. Lesiak-Watanabe, Kyoichi A. Watanabe, Steven E. Patterson, Hiremagalur N. Jayaram, Joel A. Yalowitz, Michael D. Miller, Michael Seidman, Alokes Majumdar, Gerd Prehna, and Barry M. Goldstein. J. Med. Chem. 45(3), 703-12 (2002).  Abstract.