Courtney Aldrich - Research

Complete Publication List

Gupte, A.; Celia, L.; Boshoff, H. I.; Wilson, D. J.; Neres, J.; Labello, N. P.; Somu, R. V.; Barry, C. E. III; Beck, B. J.; Aldrich, C. C. 2-Triazole Substituted Analogues of 5’-O-[N-(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective Against Mycobacterium tuberculosis. J. Med. Chem. 2008, 51, 7495-7507.

Labello, N. P.; Neres, J. Bennett, E. M.; Ferguson, D. M.; Aldrich, C. C. Quantitative Three-Dimensional Structure Linear Interaction Energy Model of 5’-O-[N-(Salicyl)sulfamoyl]adenosine and the Aryl Acid Adenylating Enzyme MbtA. J. Med. Chem. 2008, 51, 7154-7160.

Neres, J.;Wilson, D. J.; Aldrich, C. C. Aryl Acid Adenylating Enzymes (AAAE) Involved in Siderophore Biosynthesis: Development of a Fluorescence Polarization Assay, Determination of AAAE Ligand Specificity, and Discovery of Non-nucleoside Inhibitors. Biochemistry, 2008, 47, 11735-11749.

Neres, J.; Labello, N. P.; Somu, R. V.; Boshoff, H. I.; Wilson, D. J.; Vannada, J.; Chen, L.; Barry, C. E. 3rd; Bennett, E. M.; Aldrich, C. C. Inhibition of Siderophore Biosynthesis in Mycobacterium tuberculosis with Nucleoside Bisubstrate Analogues: Structure Activity Relationships of the Nucleobase Domain of 5’-O-[N-(Salicyl)sulfamoyl]adenosine. J. Med. Chem. 2008, 51, 5349–5370.

Aldrich, C. C.; Somu, R. V. Nucleoside Antibiotics as Antitubercular Agents.  In  Nucleosides in Biochemistry, Biotechnology and Medicine; Herdewijn, P., Ed.; Wiley: : Weinheim, Germany, 2008; 365–391.

Gupte, A.; Subramanian, M.; Remmel, R. P.; Aldrich, C. C. Synthesis of Deuterium-labelled 5’-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS-d4) as an Internal Standard for Quantitation of Sal-AMS. J. Label. Compd. Radiopharm. 2008, 51, 118–122.

Qiao, C.; Gupte, A.; Boshoff, H. I.; Wilson, D. J.; Bennett, E. M.; Somu, R. V.; Barry, C. E. III.; Aldrich, C. C. 5’-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Aryl Adenylating Enzyme Required for Siderophore Biosynthesis of the Mycobactins. J. Med. Chem. 2007, 50, 6080–6094.

Qiao, C.; Wilson, D. I; Bennett, E. M.; Aldrich, C. C. A Mechanism-Based Aryl Carrier Protein/Thiolation Domain Affinity Probe. J. Am. Chem. Soc. 2007, 129, 6350–6351.

Pfleger, B. F.; Lee, J. Y.; Somu, R. V.; Aldrich, C. C.; Hanna, P. C.; Sherman, D. H. Characterization and Analysis of Early Enzymes for Petrobactin Biosynthesis in Bacillus anthracis. Biochemistry, 2007, 46, 4147–4157.

Lee, J. Y.; Janes, B. K.; Passalacqua, K. D.; Pfleger, B. F.; Bergman, N. H.; Liu, H.; Håkansson, K.; Somu, R. V.; Aldrich, C. C.; Cendrowski, S.; Hanna, P.; Sherman, D. H. Biosynthetic Analysis of the Petrobactin Siderophore Pathway from Bacillus anthracis. J. Bacteriol. 2007, 189, 1698–1710.

Somu, R. V.; Wilson, D. J.; Bennett, E. M.; Boshoff, H. I.; Celia, L.; Beck, B. J.; Barry, C. E. 3rd; Aldrich. C. C. Antitubercular Nucleosides that Inhibit Siderophore Biosynthesis: SAR of the Glycosyl Domain. J. Med. Chem. 2006, 49, 7623–7635.

Vannada, J.; Bennett, E. M.; Wilson, D. J.; Boshoff, H. I.; Barry, C. E. 3rd; Aldrich, C. C. Design, Synthesis and Biological Evaluation of b-Ketosulfonamide Adenylation Inhibitors as Potential Antitubercular Agents. Org. Lett. 2006, 8, 4707–4711.

Somu, R. V.; Boshoff, H.; Qiao, C.; Bennett, E. M.; Barry, C. E. 3rd; Aldrich, C. C. Rationally Designed Nucleoside Antibiotics That Inhibit Siderophore Biosynthesis of Mycobacterium tuberculosis. J. Med. Chem. 2006, 49, 31–34.

Beck, Z. Q.; Aldrich, C. C.; Magarvey, N.; Georg, G.; Sherman, D. H. A Chemoenzymatic Synthesis of Cryptophycin/Arenastatin Natural Products. Biochemistry 2005, 44, 13457–13466.

Lakshmanan, V.; Aldrich, C. C.; Sherman, D. H.; Fecik, R. A. Formal Total Synthesis of the Polyketide Macrolactone Narbonolide. J. Org. Chem. 2005, 70, 7267–7272.

Aldrich, C. C.; Fecik, R. A.; Lakshmanan, V. Sherman, D. H. Chemoenzymatic Synthesis of the Polyketide Macrolactone 10-Deoxymethynolide. J. Am. Chem. Soc. 2005, 127, 8910–8911.

Aldrich, C. C.; Beck, B. J.; Fecik, R. A.;  Sherman, D. H. Biochemical Investigation of Pikromycin Biosynthesis Employing Native Penta- and Hexaketide Chain Elongation Intermediates. J. Am. Chem. Soc. 2005, 127, 8441–8452.

Nishizawa, T.; Aldrich, C. C.; Sherman, D. H. Molecular Analysis of the Rebeccamycin L-Amino Acid Oxidase from Lechevalieria aerocolonigenes ATCC 39243. J. Bacteriol. 2005, 187, 2084–2092.

Soulere, L; Aldrich C.; Daumke, O.; Gail, R.; Kissau, L.; Wittinghofer, A.; Waldmann, H. Synthesis of GTP-Derived Ras Ligands. Chembiochem 2004, 5, 1448–1453.

Beck, B. J.; Aldrich, C. C.; Fecik, R. A.; Reynolds, K. A.; Sherman, D. H. Substrate Recognition and Channeling of Monomodules from the Pikromycin Polyketide Synthase. J. Am. Chem. Soc. 2003, 125, 12551–12557.

Beck, B. J.; Aldrich, C. C.; Fecik, R. F.; Reynolds, K. A.; Sherman, D. H. Iterative Chain Elongation by a Pikromycin Monomodular Polyketide Synthase. J. Am. Chem. Soc. 2003, 125, 4682–4683.

Merlic, C. A.; Aldrich, C. C.; Albaneze-Walker, J. E.; Saghatelian, A.; Mammen, J. Total Synthesis of the Calphostins: Application of Fischer Carbene Complexes and Thermodynamic Control of Atropisomers. J. Org. Chem. 2001, 66, 1297–1309

Merlic, C. A.; Baur, A.; Aldrich, C. C. Acylamino Chromium Carbene Complexes: Direct Carbonyl Insertion, Formation of Münchnones and Trapping with Dipolarophiles. J. Am. Chem. Soc. 2000, 122, 7398–7399.

Merlic, C. A.; Aldrich, C. C.; Albaneze-Walker, J. E.; Saghatelian, A. Carbene Complexes in the Synthesis of Complex Natural Products: Total Synthesis of the Calphostins. J. Am. Chem. Soc. 2000, 122, 3224–3225.